The Evolution of our Understanding of the Nuances of Pathologic Cortisol Secretion.
A few highlights: Cushing syndrome refers to the classical appearance of hypercortisolism as described by Dr Harvey Cushing. Many patients with hypercortisolism or pathologic cortisol secretion do not appear cushingoid but instead have 1 or more manifestations of cortisol excess. Mild autonomous cortisol secretion is associated with cardiometabolic morbidity and mortality and, once identifed,should be treated. Patients with“normal” urine free cortisol excretion rated may, indeed, have relative hypercortisolism. Careful testing of the dynamics of cortisol secretion will enable identi cation of these patients who may require treatment
This study touches on the seminal highlights in our understanding of hypercortisolism and the nuances of cortisol secretion in disease states. A case is made to restrict the use of the term“Cushing syndrome” to those with classical features and to heighten awareness of the fact that pathologic cortisol secretion can be subtle and dangerous requiring early recognition and treatment course, today, we would proclaim that they were.
© 2025, J D Faccinetti. All rights reserved.
Dear Dr Blevins:
I myself have a pituitary tumor and Cushings disease as well. I would like your suggestions of any book that I would be able to purchase about Cushing’s Disease. I did in fact purchase the book Pituitarty Patient Its All In Your Head book, and the Hormonal Factor book which have been very informative. I would like to read some books regarding Cushings Disease in order to further my knowledge on this horrific disease. I also have joined every support group on Facebook in order to learn from other and have a support system. I think that those groups have kept me out of the nut houses since they validate what is going on with me
I also have formed friendships since we consider ourselves family. Thank you for your time in this matter
Lori Haver