Comments on a recent AACE article on the diagnosis of recurring Cushing’s Disease.

From the desk of Dr. Lewis Blevins – cofounder – This article –Diagnosis of recurrence in Cushing’s disease: American Association of Clinical Endocrinologists and American College of Endocrinology Disease State Clinical Review – summarizes recent recommendations from the American Association of Clinical Endocrinologist regarding the postoperative long-term follow-up of patients treated surgically for Cushing’s disease. Everything old is new again.   Frankly, I do not find any new helpful or useful information contained in this publication.  Still, it is worth discussing with your treating physician if you have a history of Cushing’s disease and have had surgery. The take-home messages are: long-term follow-up is important;  elevated late night salivary cortisol levels indicative of disrupted diurnal variation of cortisol secretion may be the first evidence of disease recurrence; other dynamic tests still have a role in the evaluation of patients whether they are symptomatic or not; early diagnosis permits early treatment before the ravages of the disease take hold.

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